Lynch Syndrome Singapore – Lynch syndrome is a genetic “spellcheck failure” prevents your body from repairing DNA errors. One of the most common inherited cancer conditions in Singapore, Lynch syndrome significantly increases cancer risks, in particular, colorectal cancer. It is also associated with increased risk for endometrial, ovarian, stomach, pancreatic, and a number of other cancers. Lynch syndrome accounts for around 3 percent of all colorectal cancer diagnosis.
According to SingHealth, for Lynch Syndrome, Singapore stats show that about 1 in 530 people carry it (as compared to 1 in 300 people globally). It is estimated that alarmingly, about 90% of carriers are unaware of their status, leaving families vulnerable to preventable cancers.
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Lynch Syndrome Singapore: Impact On Cancer Risks
Carriers face significantly elevated lifetime risks of cancer:
- Colorectal cancer: Up to 61% risk (vs 4% general population)
- Endometrial / uterine cancer: Up to 57% risk (vs 3% general population)
- Stomach cancer: Up to 18% risk
- Ovarian cancer: Up to 15% risk
Who Needs Testing For Lynch Syndrome? Singapore-Specific Red Flags
Consider genetic evaluation if you have:
- Colorectal/endometrial cancer diagnosed before age 50.
- More than 3 blood relatives with Lynch-related cancers (colorectal, uterine, stomach).
- Multiple primary cancers in one person.
The Private Testing Pathway: Two Critical Steps
Lynch syndrome Singapore testing options include:
- Tumour Screening (IHC/MSI Tests)
- Performed automatically when cancer tissue is analysed at private labs
- Checks for missing DNA repair proteins or microsatellite instability (MSI-H)
- Germline Genetic Testing
- For “at risk” people
- Blood test analysing MLH1, MSH2, MSH6, PMS2 genes
- Requires referral to a private genetics specialist
Lynch Syndrome Singapore Testing Cost
The cost of genetic testing for Lynch syndrome in Singapore is estimated to range from S$2,000 – $2,500 (source: Singapore Cancer Network research article).
Action Plan For Lynch Carriers
If your genetic test yields a positive result for Lynch syndrome, actions that you can take include:
- Enhanced Surveillance:
- Colonoscopy every 1-2 years starting at age 25
- Annual gynaecological exams + ultrasound for women
- Risk-Reducing Options:
- Preventive hysterectomy after childbearing
- Colectomy for recurrent polyps
- Targeted Therapies:
- Immunotherapy drugs show exceptional response for MSI-H tumours
Why Singaporeans Should Prioritise Testing
With rising early-onset cancer rates, proactive management enables:
- Cancer prevention through pre-emptive polyp removal.
- Family protection via cascade testing.
- Personalised therapies if cancer develops.
Our Preferred Doctors (Surgeons, Gastroenterologists, Urologists)
Dr Tan Wee Boon
Dr Kim Guowei
Dr Chong Choon Seng 张峻诚医生
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What Is The Next Step?
Worried about Lynch syndrome, colorectal cancer, endometrial / uterine cancer or stomach cancer? Consider speaking to a medical specialist. Contact us for assistance to get a consultation.
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